Got to simplify the process for attacks. Why not just hold down the space bar to charge your shot and release it to fire. For picking targets or making decisions on which path to take, why not use the A and D keys instead of clicking the mouse. A to go left, D to go right, Spacebar to select. The S key is fine as is so long as I don't have to take my hand off the keyboard to move my mouse. Number pad to use items.
Probably a good game, but I'll just stick to watching someone else's playthrough for the time being.